Endometrial Receptivity Array for Repeated Implantation Failure

Background: Diagnosis of endometrial receptivity (ER) has posed a challenge. Microarray technology has allowed identification of the transcriptomic signature of receptivitywindow of implantation (WOI). Use of this test in patients with recurrent implantation failure (RIF) has shown that the WOI is displaced in a quarter of these patients and use of a personalized embryo transfer (pET) on the day designated by ERA improves reproductive performance Method: Observational studies on the  Endometrial Receptivity Array for repeated implantation failure were  identified within the PUBMED and EMBASE electronic database. Results: in all of studies there is an increasedpercentage of WOI displacement in RIF patients. A significant proportion of patients with a history of implantation failure of a euploid embryo have a displaced WOI as detected by the ERA. For these patients, pET using a modified progesterone protocol may improve the outcomes of subsequent euploid FET. By transferring euploid embryos in a personal WOI, much better pregnancy rates are expected. prevalence of nucleolar channel system( NCS ) identifies the window of endometrial receptivity previously identified by their transcriptomic signature using the ERA.  the ERA is more accurate than histologic dating and is a completely reproducible method for thediagnosis of endometrial dating and receptivity status. Conclusion: ERA in patients with RIF, for guiding their pET as a novel therapeutic strategy.  

Keywords:

Endometrial Receptivity Array , Repeated Implantation Failure , Endometrial , Receptivity , FET