The Associated of Promoter Polymorphism PRCKH 1425G/A Gene with Risk of Ischemic Stroke

Introduction: one of the most common disease in nerve system is Ischemic cerebral vascular diseases (ICVDs)causes of morbidity and mortality in world. ICVDs is a heterogeneous multifactorial disease in adult patients . Otherstudies have demonstrated that the combination of genetic and environmental risk factors lead to ischemic stroke. Anumber of different pathogenic events may lead to ICVDs, including atherosclerosis, small vessel disease, cardiacdisease, and hypercoagulation . Atherothrombosis is considered to be the main cause.Age, sex, obesity, smoking,hypertension, diabetes, and dyslipidemia is reliable stroke risk predictors. PRCKH 1425G/A Is a candidate gene forstroke diseases. The present study was to explore the role of this gene in the Mashhad Ghaem Hospital patients withischemic stroke. In the present study, we performed a genetic association study about the polymorphisms PRCKH1425G/A as a susceptible gene in an North-east of Iran population with ICVDs.Methods: This case-control study included 200 stroke patients and 200 healthy controls. These two groups werefrom 20 to 70 years old, randomized gender and other demographic factors. In this study, patients who referred tohospital and diagnosed with stroke, identified as ischemic or hemorrhagic stroke by brain CT & MRI. We selectedthe ischemic patients and performed DNA extraction PRCKH 1425G/A polymorphisms were discovered by PCRARMSmethod. data was analyzed by SPSS software (version 11.5) and individuals without stroke as control group.Conclusion: PRCKH 1425G/A is associated gene for stroke diseases. Various studies have shown different resultsin different populations. We do this study to investigate the effect of this gene in patient with ICVDs in North -eastof Iran population.

Keywords:

5-lipoxygenase activating protein (ALOX5AP) , Ghaem Hospital , Ischemic stroke , ICVD