Oxidative aromatization of some 1,4-dihydropyridines by aqueous hydrogen peroxide in ethanol
Publish place: Iranian Chemical Communication، Vol: 3، Issue: 2
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_ICC-3-2_009
تاریخ نمایه سازی: 1 مرداد 1397
Abstract:
Some 3,5-diacyl or 3,5-diester 1,4-dihydropyridines were oxidized to the corresponding pyridinederivatives using hydrogen peroxide in aqueous ethanol in the presence of potassium bromideand acetic acid as the catalysts. The reaction was carried out in ethanol and the products wereisolated in high to excellent yields. However, oxidation of 3,5-diacetyl 1,4-dihydropyridines isslower than 3,5-diester 1,4-dihydropyridines under the same condition. Furthermore, the reactionis facilitated by electron releasing groups on 4-substituent of dihydropyridine ring. Thecheapness of reagent, high yielding, easy workup and mild condition makes this method a usefuladdition to the available method in organic synthesis. In addition, employment of clean oxidantH2O2 together with nontoxic solvent ethanol makes it friendly to the environment.
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Authors
Masumeh Abdoli-Senejani
Department of Chemistry, Islamic Azad University-Arak Branch, P.O. BOX ۳۸۱۳۵-۵۶۷, Arak, Iran
Maryam Hajibabaei
Department of Chemistry, Islamic Azad University-Arak Branch, P.O. BOX ۳۸۱۳۵-۵۶۷, Arak, Iran