Synthesis of some network polymers with siloxane units as a drug delivery system

Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_ICC-3-4_005

تاریخ نمایه سازی: 1 مرداد 1397

Abstract:

New biodegradable network polymers containing siloxane-linked polymeric prodrugs of 5-ammino-2-hydroxybenzoic acid (5-ASA) in the main chain were prepared by terpolymerizationof methacrylic acid; (MA), 2-hydroxyethylmethacrylate (HEMA), and bis (trimethylsilyloxy)methylsilane (VBM) in the presence of some new cross-linking agents. The monomers andpolymers were characterized by FT-IR and 1H-NMR spectroscopy, and studied by DSC analysis.The hydrolysis of them was carried out in cellophane membrane dialysis bags containing aqueousbuffer solution at 37ºC. Detection of the hydrolysis product by UV spectroscopy showed thatattaching of siloxane units in these hydrogels modified this drug delivery system.

Authors

Mohammad Galehassadi

Department of Chemistry, Azarbaijan Shahid Madani University, Tabriz, Iran

Samad Omidi

Department of Chemistry, Azarbaijan Shahid Madani University, Tabriz, Iran