Synthesis of some network polymers with siloxane units as a drug delivery system

New biodegradable network polymers containing siloxane-linked polymeric prodrugs of 5-ammino-2-hydroxybenzoic acid (5-ASA) in the main chain were prepared by terpolymerizationof methacrylic acid; (MA), 2-hydroxyethylmethacrylate (HEMA), and bis (trimethylsilyloxy)methylsilane (VBM) in the presence of some new cross-linking agents. The monomers andpolymers were characterized by FT-IR and 1H-NMR spectroscopy, and studied by DSC analysis.The hydrolysis of them was carried out in cellophane membrane dialysis bags containing aqueousbuffer solution at 37ºC. Detection of the hydrolysis product by UV spectroscopy showed thatattaching of siloxane units in these hydrogels modified this drug delivery system.

Keywords:

Cross-linking , siloxane , methac rylate , vinylsilane , drug loading