Effect of Chemotherapy on Zinc, Copper, Vitamin D Levels and Inflammatory Marker in Adult Acute Lymphoblastic Leukemia

Background: In acute lymphoblastic leukemia (ALL) the bone marrow loses itsability in the differentiation and maturation of blood cells at different stages.Zinc and copper are important co-factors for several enzymes and play animportant role in maintenance of DNA integrity. Changes in serum levels of zincand copper have been found in lymphoproliferative disorders. In the presentstudy, the aim was to compare serum levels of zinc, copper, vitamin D,and inflammatory markers after eight courses of chemotherapy. Methods:Participants of this study included 30 ALL patients in the age range of 15 to 65years. A 10 mL blood sample was taken before and after eight courses ofchemotherapy. The concentration of Zinc, Copper, hs-CRP, vitamin D andmalondialdehyde (MDA) were measured. Results: There was a significantincrease in serum zinc (121.7 ± 18.05 μg/dL before chemotherapy and 156.6 ±25.00 μg/dL after chemotherapy) and a significant decrease in serum copper(661.9 ± 190.1 μg/dL before chemotherapy and 402.2 ± 93.5 μg/dL afterchemotherapy) and a significant decrease in Malondialdehyde and serum vitaminD were observwd. Further, no significant differences were observed in hs-CRPafter chemotherapy. Conclusion: Results showed that chemotherapy coulddecrease the burden of disease by increasing serum zinc and decreasing serumcopper.

Keywords:

Acute lymphoblastic leukemia , Serum zinc and copper , Inflammation status