INVESTIGATION OF RESISTANCE RATE TO AMINOGLYCOSIDES, BETALACTAM, FLUOROQUINOLONES AND TETRACYCLINES IN ENTEROBACTERIACEAE ISOLATES FROM TABRIZ

Background and Aim:Background: One of the most common Gram-negative bacteria isolated from microbiology laboratories is Enterobacteriaceae. Enterobacteriaceae have an important role in nosocomial infections, pneumoniae, and local infections after surgery and septicemia. Common treatments for Enterobacteriaceae infections are aminoglycosides, beta-lactams, fluoroquinolones and tetracyclines. This study investigated antibiotic resistance patterns in Enterobacteriaceae isolates from Hospitals of Tabriz, Iran.Methods:Material and Methods: A total of 250 Enterobacteriaceae isolates were gathered from clinical specimens. The organisms were identified by the microscopic feature and the differential tests. The disk diffusion susceptibility testing was performed according to the Clinical and Laboratory Standards Institute (CLSI) guidelines with 20 antibiotics.Results:Results: According to the disk diffusion agar, the highest resistance rat was observed to ampicillin (97%), cotrimoxazole (72.6%), cefazolin (69.6%), nalidixic acid (66.4%), tetracycline (58.8), ciprofloxacin (50%), aztreonam (44.8%), doxycycline (43.6%), cefepime (39.3%), gentamicin (37.2%), ceftazidime (33.2%), amoxicillin/clavulanate (29.2%), nitrofurantoin (25.6%), minocycline (24%), piperacillin/tazobactam (14.4%), amikacin (8.9%), meropenem (4%), imipenem (3.6%), fosfomycin (1.6%) and tigecycline (0.4%).Conclusion:Discussion: According to the results of the antibiotics susceptibility patterns, indicate that the high frequency of resistance was found to some β-lactams, sulfamethoxazole, tetracycline, quinolone and aminoglycoside agents. This finding is similar to other studies from Iran. Amikacin, carbapenems, fosfomycin and tigecycline were most effective antimicrobial agents in this area.

Keywords:

Enterobacteriaceae , resistance , aminoglycoside , betalactam , fluoroquinolone , tetracycline