ANTIMICROBIAL EFFECT OF ATRAGIN HERBAL CREAM ON DIFFERENT MICROBIAL ISOLATES

Background and Aim:The emerging problem in treatment of infectious diseases are the rapidly increasing drug resistance to currently recommended antibiotics. Atragin cream is a miracle herbal medicine complex for treatment of chronic wounds like Bedsore, Diabetic Foot Ulcer, surgical wounds. This cream include a mixture of natural product complexes from more than nine different components. The aim of the study was to examine the antimicrobial effects of Atragin herbal cream on different microbial isolates.Methods:The bacterial isolates were used for this study include Staphylococcus aureus (RTCC1885), Staphylococcus epidermidis( RTCC1892), Streptococcus pyogenes ( RTCC1911), Bucillus subtilis (RTCC1053), Bucillus cereus (RTCC1046), Bucillus anthracis (RTCC 1036), Pseudomonas aeruginosa (RTCC1477), Acinetobacter baumanii (RTCC1015), Escherichia coli (RTCC2325).The susceptibility of isolates to the Atragin herbal cream was evaluated using disk diffusion, cylinder, well diffusion, MIC and MBC methods.Results:The results showed that Staph. aureus, B. subtilis, B.cereus,B. anthracis, P. aeruginosa , A. baumanii were susceptible to the Atragin herbal cream and Staph.epidermidis, E.coli and Strep.pyogenes were resistant. The results of MIC of the Atragin cream was: Staph. aureus (3 mg/ml) , B. subtilis (3 mg/ml), B.cereus (7.5 mg/ml), B. anthracis(12.5mg/ml), A. baumanii (12.5 mg/ml), P. aeruginosa ( 25 mg/ml).Conclusion:The results of this study demonstrate that the most susceptible isolates were Staph. aureus, B. subtilis, B.cereus. Atragin herbal cream has a broad in vitro spectrum of antimicrobial activity against some bacterial pathogens and may be particularly useful for treatment of infections by multidrug-resistant organisms.

Keywords:

Atragin herbal cream , Antimicrobial effect , bacterial isolates