A CASE OF HUMAN WRIST SYNOVIAL INFECTION CAUSED BY ACCIDENTAL INJECTION OF ANIMAL VACCINE

Background and Aim:Brucellosis, a zoonotic disease caused by different species of Brucella. The attenuated strain B. abortus S19 has been the vaccine most widely used to prevent bovine brucellosis. Infection due to these vaccines is usually acquired from conjunctival splashes, skin cuts or, occasionally, infectious aerosols, and generally occurs in individuals involved in animal vaccination. Here we describe the case of wrist Synovial infection due to accidental self-injection of Brucella vaccine.Methods:A 35-year-old veterinarian during vaccination in cattle has accidentally injected about 0.1 ml of the vaccine suspension vaccine into the wrist. The past history of the patient and the serological follow-up of animals contacted by the professional did not evidence other risk contacts. One month after accidentally self-injection he consults the physician because of wrist pain. He didn t have systemic symptoms of brucellosis.Results:Microscopic examination of abscess discharge showed a large number of gram-negative bacilli and also a large number of neutrophils. PCR showed the presence of Brucella Spp. in the sample. Serologic follow up after two months on blood samples was negative for brucellosis.Conclusion:The most of cases of occupational brucellosis infected due to accidental injection, facial splashes or skin exposure. In our study blood, the culture was negative and vaccine strain couldn t produce systemic symptoms such as fever, sweat, ague and weight. Our patient didn t have the history of brucellosis and post-treatment serologic and microbiologic follow up didn t show signs of brucellosis. This could be due to different nature of live attenuated vaccine strain that was a weak strain.

Keywords:

Brucella , S19 , Vaccine , PCR