REPORTING TWO CASES OF STOMACH CARCINOMA WITH HELICOBACTER PYLORI RESISTANT TO CLARITHROMYCIN AND METRONIDAZOLE

Background and Aim:Helicobacter pylori infection is one of the common infections of the digestive tract that leads to gastritis, peptic ulcers, and finally stomach cancerMethods:This case study deals with two female patients 65 and 59 year old diagnosed with adenocarcinoma of the stomach pylorus with chronic gastritis and helicobacter pylori infection. Both patients were diagnosed with gastric cancer, chronic gastritis, and gastric ulcer 5 and 3 years ago and they were treated with a pharmaceutical mix of Lansoprazole, Amoxicillin, Clarithromycin, and Metronidazole for 2 weeks and 40 days later after they underwent endoscopy they showed gastric ulcer improvement. But after 5 and 3 years, when this study was conducted on the patients referring to the Gastroenterology Ward in hospitals in southern Iran, adenocarcinomas was diagnosed in the pyloric area based the results of endoscopy, CT Scans, and pathological slides, and biopsy testsResults:Simultaneously, Helicobacter pylori were isolated and cultured and antibiotic resistance testing was performed. Although nuclear P53 levels dropped, it was still traceable. HER2 was also diagnosed through immunohistochemistry. The results of the antibiotic resistance testing indicated that both isolated samples were resistant to metronidazole and clarithromycin.Conclusion:HER2 was also diagnosed through immunohistochemistry. The results of the antibiotic resistance testing indicated that both isolated samples were resistant to metronidazole and clarithromycin.

Keywords:

Stomach carcinoma , Helicobacter Pylori , Antibiotic Resistance , Clarithromycin