HUMAN PAPILOMA VIRUS STUDY IN PATIENTS WITH BREAST CANCER IN ISFAHAN, 1396

Background and Aim:: Viruses such as Human Papiloma viruses have been identified in benign and breast cancerous tissues and have been considered as an etiology of breast cancer, but there is controversial information about the induction of viral breast cancer . The aim of this study was to determine the presence of Human Papiloma virus in patients with pre-existing breast cancer in Isfahan city .Methods:: In this study 43 cases of breast cancer were investigated to detect the human Papiloma virus DNA with a high risk of malignancy using a PCR molecular method with selective viral primers .Results:HPV DNA sequences were observed in 8 samples of breast cancer that 2 were reported with a high risk of malignancy.Conclusion:The association between Human Papiloma virus infection in cancer tissue depends on the many factors , and our results can not confirm the role of HPV in breast cancer.

Keywords:

Human Papiloma virus , breast cancer , PCR