ANTI-CANDIDA ACTIVITIES OF SEEDS HYDROALCOHLIC EXTRACT OF RUMEX OBTUSIFOLIUS

Background and Aim:Nowadays, the uses of herbal medicines have increased in the prevention and treatment of diseases in the world, especially Iran. The development of resistance in some Candida species and side effects of chemical drugs consumption new resources especially medicinal plants is very important. The purpose of this study was to investigate of anti-Candida activities of hydroalcohlic extract from seeds of Rumex obtusifolius.Methods:The Rumex obtusifolius seeds were extracted using Ethyl acetate: methanol: distilled water (6:3:1) by Soxhelet system. The antifungal activity was examined. The extract was screened against 40 isolated pathogenic Candida species such as C. albicans, C. glabrata by agar well diffusion method.Results:The minimum inhibitory concentration values at 24 and 48 hours were 100-150 μg/μL for C. albicans 150 μg/μL for C. glabrata.Conclusion:The seed of Rumex obtusifolius has strong anticandidial antioxidant activities. This seems may be correlated to the presence of high levels of phenolic compounds, particularly pyrogallol.

Keywords:

Rumex obtusifolius , Candida , Hydro alcoholic extract , Seed