ANTIMICROBIAL EFFECT OF AQUEOUS AND HYDROALCOHOLIC EXTRACTS OF PLANTAGO PSYLLIUM AGAINST EXPERIMENTAL INFECTION OF HELICOBACTER PYLORI IN FEMALE RAT

Background and Aim:pharmaceutical microbiologyMethods:Fifty female rat of Sprague Dawley race were divided into five groups of equal numbers. One group served as a negative control group and the other as a positive control group. After isolating and culture, Helicobacter infection was examined by hospital samples. Except of the negative control group, the remaining groups received 0.5 ml of solution containing 2×107 cfu/ml Helicobacter pylori .Groups 2 and 3 were treated with aqueous and hydro-alcohol extracts of 100mg/kg concentration respectively. They received 300 mg of extract per kg of body weight. The group 4 with a solution of 50 mg amoxicillin concentrations was treated, which receiving 50 mg of antibiotics for per 1 kg of body weight daily. Positive and negative control group were not treated.Results:: All groups except the positive control group, were negative for antigen in stool, which indicates the effectiveness of the treatment. Experiments suggested that extracts does not affect the process of disease recovery which is because of the small size of the samples. Statistical analysis showed that blood samples have not significant difference in terms of factors affecting liver and kidney.Conclusion:The extract of the P.psyllium can be used as a selective treatment for Helicobacter pylori infection.

Keywords:

plantago Psyllium , Helicobacter pylori , amoxicillin , gastric cancer