Association of Angiotensin-converting enzyme (ACE) insertion/deletion gene polymorphism with risk of schwannoma in patients referred to Imam Khomeini Hospital in Tehran

Angiotensin converting enzyme gene is located in 17q23.3 chromosomal site with functional insertion/deletion polymorphism. The frequency of cases with DD genotype is higher than that of genotypes ID and II. In this study, the association between the gene and the brain cancer of schwannoma was investigated. This case-control study was conducted on 31 patients with brain cancer of schwannoma and presence of 20 health control group. ACE I/D polymorphism was detected by the Gap-PCR technique. PCR products were isolated and measured by electrophoresis on 2% agarose gel.The Insertion (I) allele was observed in the band of 478 bp and the Deletion allele (D) in the 191 bp band. It was estimated that the absence of genotype ID is related to the probability of developing brain schwannomic cancer. Also, DD and II genotypes had a p-value greater than 0.05 and the hypothesis of their association with brain invasion was rejected. Considering the results, it should be noted that these findings are the first report of the association between ACE I/D polymorphism and schwannoma. Further studies are needed to confirm these findings.

Keywords:

Angiotensin converting enzyme , ACE I/D polymorphism , Brain cancer , Schwannoma , Gap-PCR