Determination Electrochemical of diclofenac Sodium at Multiwalled Carbon Nanotube/Fe3O4 Nanopartical Modified Pencil Electrode

A sensitive and novel chemically multi-walled carbon nanotubes /Fe3O4 Nanopartical modified pencil graphite electrode(MPGE) has been developed for the electrochemical investigation of diclofenac sodium (DIC). MPGE was characterized by scanning electron microscopy (SEM) and cyclic voltammetry (CV), respectively. The experimental conditions were optimised by means of investigating the dependence of peak current on solution pH, concentration , scan rateand amount of MWCNTs/ Fe3O4 etc. Various strategies for modification of the PGE by MWCNTs/ Fe3O4 were examined and concluded that the drop coating of PGE has the best performance. Differential pulse voltammetry (DPV) was used for the determination of DIC. Under optimized conditions, The oxidative peak currents were varied linearly with concentration in the range between 0.47–13.35μM with a detection limit of 0.17μM. The MWCNTs /Fe3O4 Nano Composite Modified Pencil Electrode was used for the determination of DIC in real samples, including pharmaceutical and biological samples, and the good accuracy of the modified electrode was confirmed by acceptable recovery values.

Keywords:

diclofenac sodium , modified pencil graphite electrode , voltammetry