Seyed Mohammad Amin Kormi - Cancer Genetics Research Unit, Reza Radiation Oncology Center, Mashhad, Iran
Shima Ardahkhani - Department of Biology, Faculty of Sciences, University of Zabol, Zabol, Iran
Mohammad Amin Kerachian - Institute of Social Security and Weleare Applied Science Higher Education Tehran Province, University of Applied Science and Technology, Tehran, Iran
Mohammad Amin Kerachian - Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Osteoporosis is considered as one of the most common diseases that women face after their menopause and is caused by both genetic and evironmental factors. Dipeptidyl peptidase 4 )DPP-4) gene is one of the important genetic factors contributing in osteoporosis which has a direct and very important relationship with fasting. Fasting is one of the alternatives proved to reduce the DPP-4 level and activate the Dipeptidyl peptidase 4 inhibitors and so, prevent osteporosis. On the other hand, the circadian rhythm has a direct relationship with osteoporosis. This has been found by the biochemical markers, indicating that fasting at certain hours of the day, especially during those hours of the day which are recommended as part of the Muslim tradition, is very effective in reducing the effects of osteoporosis.

Circadian Rhytm, Dipeptidyl Peptdase 4, Fasting, Osteoporosis