The relationship between serum level of high sensitive hs-CRP and severity of pre-eclampcia and compare with normal pregnancy

Introduction: The aim of this study was to determine the level of plasma high sensitive c-reactive protein (hs-CRP) in preeclampsia and to compare hs-CRP levels between normal pregnant women, mild preeclamptic, and severe preeclamptic women. Methods: Serum hs-CRP levels were investigated in 50 cases of normal pregnant women, 45 cases with mild preeclampsia and 42 cases with severe preeclampsia in the third trimester of pregnancy. Venous blood samples were collected at admission to the hospital at least 6h beforedelivery for measurement of hs-CRP by immuno turbidometric method with bionic kit. The student t test and ANOVA and X2 were usedfor comparison of proportions. C-reactive protein was measured in maternal serum using a highly sensitive method with a detection limit of 2mg/L. The study conducted between 2013 October -2014 February Results: There were significant difference in the means serum hs-CRP between normal pregnant women and mild preeclamptic women (P<0.05). Serumconcentration of hs-CRP were significantly higher in severe prceclampsia (p<0.05) than normal pregnancy.There were also significant differences in hs-CRP levels between mild and severe preclampsia (P<0.05). Conclusion: We found higher levels of hs-CRP in mild and severe preeclampsia than normal pregnancy and also these results suggest that hs- CRP are increased more in severe preeclamsia than mild preeclampsia , and may be useful in prediction and diagnosis of the severity of preeclampsia.

Keywords:

C - reactive protein , severity of disease , preeclampisa