Value of determination of serum glucose 6 phosphate isomerase in patients with rheumatoid arthritis and correlation with disease activity

Introduction: Rheumatoid arthritis is a common multi systemic autoimmune disease with peripheral joint involvement. Many autoantibodies have been introduced in the course of rheumatoid arthritis, some of them have diagnostic and prognostic value. Material and Method: 87 known cases of rheumatoid arthritis who referred to Shahid Motahari Clinic of Shiraz University of Medical Sciences in 2015 and 76 healthy controls selected. Serum glucose-6-phosphate isomerase was measured with sandwich ELISA method in both groups and level of the enzyme compared with disease activity, disease duration, ESR, CRP, RF and anti CCP antibody.The data were analyzed by using SPSS V 16 software. Results: Positivity for glucose-6-phosphate isomerase was detected in 34.5 % (30/87) of rheumatoid arthritis patients and 9.2% (7/76) of control group (p value<0.001). There was no significant correlation between enzyme level and disease activity, disease duration, ESR, CRP, RF and anti CCP antibody. Discussion and Conclusion: Overall in our study, although there is significant difference in serum G6PI concentration, between patient and control group, most of the patients showed no positivity, also about 11% of control group were positive. So it doesn t seem to be a reliable marker according to our study. There was no significant correlation between serum G6PI level and disease activity, ESR, CRP and anti CCP antibody, but relative correlation with ESR and disease duration can be challenging.

Keywords:

Rheumatoid arthritis , glucose 6 phosphate isomerase