Evaluation of the role of nuclear magnetic resonance (NMR) in Detection of myopathies and compare it with biopsy

Introduction and objectives: Muscle diseases represent a wide variety of both acquired and hereditary disorder. Five main entities are recognized: (1) dermatomyositis ; (2) polymyositis ; (3) necrotizing autoimmune myopathy (4) sporadic inclusion body myositis ; and (5) non-speciï پc myositis. Interviews, physical examinations, genetic tests, electrodiagnosis, and muscle tissue biopsies are all used to diagnose neuromuscular diseases. Histopathologic examination of muscle is invaluable in the evaluation ofmost patients with suspected myopathy. Although generally safe and well-tolerated, open muscle biopsy is costly and requires the assistance of a surgeon, an operative theater, and local or regional anesthetics . Now nuclear magnetic resonance (NMR) offers a new opportunity for life vision of muscle-what has been termed a magnetic eye on metabolism . In this article we draw attention to the potential of NMR for study of muscle composition and metabolism. Search method:We performed a systematic review with search the following electronic databases such as MEDLINE and EMBASE databases with use of keywords such as NMR, myopathy, muscle biopsy and pathology , in search engine such as sciencedirect ,pubmed to identify reports of relevant muscle NMR and diagnosis of muscle myopathy and compare it with biopsy . Results:Topical NMR has been shown capable of indicating comparable changesi. e., low phosphorylcreatine, raised Pi, and acid shift of pH when circulatory oxygen supply to muscle has been arrested-both in animals and in man. Another prospect offered by NMR is the direct determination of protein synthesis rates by measurement of the incorporation of 13C-labelled leucine into muscle protein (an investigation which at present requires needle biopsy sampling). In view of its potential in the investigation and treatment of myopathy, development of this method deserves some priority. Conclusion : A major concern is that as the pathology is often patchy the biopsy may not show an inflammatory infiltrate although it may be present in other parts of the muscle .NMR is as a rapid, non-invasive method of investigating undiagnosed muscle weakness. The outlook for metabolic studies of myopathy by NMR seems very promising.

Keywords:

NMR , muscle biopsy , myopathy , pathology