Clinicopathologic Variants of Mycosis Fungoides

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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DNWMED04_027

تاریخ نمایه سازی: 5 آذر 1397

Abstract:

Mycosis fungoides (MF) is the most common primary T- cell cutaneous lymphoma and accounts for almost 50% of all primary cutaneous lymphomas. Classic MF starts with a nonspecific phase consisting of erythematous macules that can last for years. In sub- sequent phases, patients develop plaques and, in some cases, tumors. Enlarged lymph nodes, visceral involvement, and transformation to large- cell lymphoma are less common findings that are typically seen in advanced stages of the disease. Numerous clinical and histopathologic variants of MF have been described in recent decades. Although some of these variants have been reported as isolated cases, others have greater clinical relevance due to their relative frequency and their therapeutic and prognostic implications. The wide range of clinical and pathological presentations of early-stage MF requires a broad differential diagnosis as early lesions can mimic many of the patterns seen in cutaneous inflammatory disorders.Here we review the main clinical, histopathologic, and immunohistochemical characteristics that help to establish a correct diagnosis of MF, particularly in the early stages of disease. We also describe the distinctive clinical and pathological features that define the different variants of MF.

Authors

Armaghan Garehaghaji Zare

Department Of Dermatology, Tabriz University of Medical Science