Electrochemical Synthesis of PEI/PVP Coated Superparamagnetic Iron OxideNanoparticles for Biomedical Applications

In the recent decade, there has been a considerable development of magnetite nanoparticles(MNPs) for biomedical applications like magnetic carriers for drug delivery and targetingsupported by external magnetic fields, magnetic resonance imaging (MRI) contrast agents forclinical diagnosis, cancer therapy compounds for hyperthermia, etc. [1-3]. SuperparamagneticFe3O4 nanoparticles double coated with poly(vinylpyrrolidone)/polyethylene imine polymerswere successfully fabricated through cathodic electrochemical deposition. In this method, in situpolymer coating of the surface of Fe3O4 nanoparticles was achieved through electrodepositionprocess. The evaluation by XRD analysis confirmed that the electrodeposited nanoparticles arecomposed of pure phase of iron oxide i.e. magnetite (Fe3O4). The structure and composition ofthe prepared nanoparticles were characterized by SEM, TEM, DLS, XRD, FTIR, and TGanalyses. The DLS analysis revealed that the bare and prepared polymer coated Fe3O4nanoparticles have size of 20 nm and 72 nm, respectively. The polymer coated nanoparticleswith having 15 nm in size, suitable magnetization value (Ms=25 emu/g), and negligiblecoercivity (Ce=0.62 emu/g) and remanence (Mr=1.5 Oe) are proper candidate for biomedicalapplications. This electrochemical strategy is proposed as facile and efficient route forpreparation of polymer coated Fe3O4 nanoparticles.

Keywords:

Magnetite , Electrochemical deposition , Polymer coating , Biomedical Applications