Development of Bilayer Lyophilized Wafer for Treating Wounds by Using Moxifloxacin as an Antibiotic

Wafers, as porous modern wound dressings, have some advanced properties such as; ability to absorb exudate, providing optimum moisture balance and gaseous exchange at the wound surface leading to reduced risk of fluid accumulation and infection risk. In this study, we designed and optimized a bilayer lyophilized Moxifloxacin loaded wafer and evaluated its wound healing properties in vitro and in vivo. Bioadhesion force, drug release profile and swelling index was optimized using Design Expert v7 software. To evaluate the efficacy of optimized wafer, disc diffusion test and wound healing experiment applied. Faster wound healing and pathologic evaluation of treated wounds proved the efficacy of optimized wafer. Addition studies, differential scanning calorimetry and scanning electron microscopy, indicated presence of Moxifloxacin crystals on the surface of polyvinylpyrrolidone and gelatin surface which explained the release profile of Moxifloxacin from wafers.

Keywords:

Wound Healing , Modern Wound Dressing , Tissue Engineering , Moxifloxacin , Wafer