Investigating Healing Effects of Aloe Vera Extract and Mesquite Pod Fruit Extract on Skin lesions in Rats

Today with unfavorable impacts and side effects of chemical drugs, traditional medicine and prescription of herbal plants have attracted specific attention. Treatment and healing of lesions can be considered among major issues which human has faced from the first of creation. Using Aloe vera extract and powder of mesquite pod fruit extract has been long common in Iran for treatment of skin lesions. Therefore, the present study aims to investigate quick healing and restoration effects of mesquite pod fruit extract as we ll as Aloe vera extract on laboratory rats. The research was a laboratory trial which was done on 50 rats which were divided randomly into five groups including ten rats after complete anesthesia and creating spinal injuries in completely similar conditions and characteristics. For treatment, five interventions were used as follows: 1. Normal saline solution (0.9% physiologic serum); 2. Mesquite pod fruit extract (with density of 0.5 to 99.5% solvent); 3. Pure Aloe vera extract; 4.Combination of mesquite pod fruit extract and Aloe vera extract (95% Aloe vera extract and 0.5% mesquite pod fruit extract); and 5.Nitroforazone 1% ointment (positive control). Features including 1. Rats body temperature, 2.Testing injury site blood, 3.Lesion extent, 4.Histology microscopic experiment during sixteen days of treatment were measured and collected data were analyzed using SPSS statistical software by mean+-SEM as well as survival analysis tests at significance level of 0.05. According to the results, intervention by combination of mesquite pod fruit extract and Aloe vera extract is significantly better regarding all features studied, while given the feature of lesion extent it shows a significant difference in treatment and healing of the lesion. Results of a study done by NakhaiMoghadam and colleagues confirm the results obtained by the present study

Keywords:

Lesion , Healing , Mesquite Pod Fruit Extract , Aloe Vera Extract , Laboratory Rats