Effect of Ozone Therapy Evaluate on Wound Healing

Background and objective: Treatment of non-healing wound is one of the clinical challenges. Some studies report that ozone therapy can treat chronic, diabetic, posttraumatic and non-healing wounds. Ozone therapy is an alternative therapy that is safe and useful for some disease such as AIDS, cancer, multiple sclerosis, and heart diseases. In the ozone therapy, oxygen is injected into the body via different methods include vaginal, rectal, intramuscular, subcutaneous and intravenous. The aim of this study is to review the effect of ozone therapy on wound healing. Method: This review article was carried out by searching in electronic databases such as PubMed, Google Scholar, and SCOPUS by using the search terms ozone therapy , wound healing , chronic ulcer . A selection of relevant English-language clinical trial, systematic reviews within the last 11 years (2007- 2016) was performed. Results: Studies show that the effect of ozone therapy on various wounds is different. In the diabetic patient with foot ulcers and on the healing process of 2nd-degree burns, ozone treatment reduces the size of the wound. And after treatment, the expressions of vascular endothelial growth factor (VEGF), transforming growth factor B (TGF-B), and platelet-derived growth factor (PDGF) proteins in the ozone group were more than the control group. Ozone therapy is a simple treatment for Buruli ulcer and can be used as an alternative therapy. Conclusion: In blood, ozone almost immediately disintegrates forming reactive oxygen species and lipid oxidation products. Reactive oxygen species cause platelet aggregation and release of platelet-derived growth factors, transforming growth factor B, and interleukin-8, which play a major role in rapid wound healing. According to the results, Ozone therapy has been shown speed up the healing process, reduce the pain, modulate the immune system, and act as an antibacterial agent. So, it is an effective treatment for wound healing.

Keywords:

Ozone Therapy , Wound Healing , Chronic Ulcer