The Use of Naringin-loaded PCL/Gelatin Nanofiber Scaffold as a Wound Dressing

Abstract: In the present study, naringin, a flavonoid isolated from the grape and citrus fruit species, was incorporated with poly (ε-caprolactone)/gelatin composite mats in order to develop a potential wound dressing. The composite mats were prepared by electrospinning of poly (ε-caprolactone)/gelatin (1:1 (w/w)) solution incorporated with 1.50 %, 3 % and 6 %( w/w) of naringin. The electrospun mats were evaluated in vitro and in vivo wound healing activity. The study showed that after 2 weeks, the full-thickness excisional wounds of Wistar rats treated with the naringin-loaded dressings achieved a wound closure of higher than 94 % and the dressing containing 6 % (w/w) naringin had almost 100 % wound closure. The sterile gauze, as the control group, showed nearly 86 % of wound closure after this period of time. Our results provided evidence that supports the possible applicability of naringin-loaded wound dressing for successful wound treatment.

Keywords:

Electrospinning , Gelatin , Naringin , Poly(ε-caprolactone) , Wound dressing