The First international Congress of Iranian Personalized Medicine- Tehran, February 25-27, 2017 Toward a World Alliance of Health and Wellness based on Systems P4 Medicine and Citizen Science.

Publish Year: 1395
نوع سند: مقاله کنفرانسی
زبان: English
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IPMCMED01_013

تاریخ نمایه سازی: 23 آذر 1397

Abstract:

Systems biology approaches are combining high-dimensional functional genomics data with biological, clinical, environmental and lifestyle assessments through iterative statistical analyses, computational modelling and experimental validation. They are transforming biomedical research and clinical practice, triggering the transition from a reactive to a proactive practice of medicine (1-2). This is revolutionizing how medicine will be practiced in the 21st century (3-5). The effective development of participatory, personalized, predictive and preventive (P4) systems medicine requires harmonization of experimental and computational methods for data, information and knowledge collection, storage, analysis and sharing on a big data scale using high-performance cloud computing infrastructures ensuring data security and compliance with personal data and privacy protection regulations. In order to address the associated ethical, legal and social issues, the active participation of all stakeholders including researchers and clinicians in academy and industry, regulatory and funding bodies, individuals and patient organizations is thus essential. Two examples of individuals who have managed to anticipate the occurrence of disease and take preventive measures through a regular assessment of their exposome monitored through connected mobile devices (environmental and occupational exposures, nutrition, sleep, exercise, stress), clinicome (biological and clinical features), and integrome (metabolomics, proteomic, transcriptomic, epigenomic, genomic and genetic features) provide the basis for effective implementation of systems P4 medicine (6-7). The Vistera Project initiated by EISBM in Lyon, Nantes and Paris in partnership with ISB have been designed to scale up the monitoring of wellness, health and disease through the collection of billions of data points for increasing numbers of individuals who are healthy, at risk of developing disease, or in the course of disease development, with the active participation of individuals through social networks (8). The EISBM-ISB pilot studies form the basis for the development of a worldwide network of systems medicine centres including prominent research and hospital centres such as the Luxembourg, New Delhi and Shanghai Centres of Systems Biomedicine. Through their commitment to implement the open standard protocol of the Vistera Project and enforce full compliance with personal data and privacy protection regulations under the umbrella of a World Alliance for Health and Wellness, this network will catalyse the transformation of healthcare delivery and the transition toward emphasis on management of wellness through citizen science. By monitoring individuals over a long period of time, the Vistera Project will provide them with actionable recommendations to maintain their state of health and wellness, detect early events indicative of a risk or a transition to disease, enabling their management and reversal. The expectation is that expanding the monitoring from one to millions then billions of individuals over the next 25 years, the Vistera Project will trigger in one generation a reversal of the escalating costs of healthcare management, drug and diagnostic development, providing the basis for a more cost-efficient and sustainable integrated healthcare system.

Authors

Charles Auffray

European Institute for Systems Biology & Medicine (EISBM)- Lyon - France CNRS-ENS-UCBL-INSERM - Campus Charles Mérieux – Université de Lyon