Cyp2c8 GENE POLYMORPHISM AT POSITION cyp2c8 2 805 (A → T) IN HEALTHY POPULATION OF WEST MAZANDARAN PROVINCE

Personalized medicine is a form of medicine that uses information about a persons genes, proteins, and environment to prevent, diagnose and treatment of disease. The exact purpose of showing certain elements in personalized medicine is based on an individual analysis of genomic and biological factors and lifestyle person When you choose the right medication at the right time with the disease s treatment However, such tests can test applications in personalized medicine point out that CYP2C8 genotype of cytochrome P450 enzymes of the cytochrome P450 family plays an important role in the metabolism of a variety of exogenous and endogenous compounds and drugs .this study aimed to investigate common polymorphisms in gene cyp2c8a in healthy population of west Mazandaran province to determine the polymorphism of this gene in the population studied. A total of 200 unrelated healthy volunteers living in Tonekabon, Ramsar during the period January to March 94 were referred to the laboratory. 5 mL of peripheral blood was taken from each subject and DNA was extracted using phenol-chloroform method and the PCR-RPLP method for determining the genotype of the polymorphism CYP2C8 2 805 (A → T) was used. The frequencies of genotypes AA, AT, TT, respectively, 85%, 7.5%, 7.5%, respectively P≤0.05)) based on the results obtained in this study, among the 200 samples analyzed, the highest genotype is homozygous AA. The results of this study to understand the distribution polymorphism 805 (A → T) of the genes CYP2C8 2. Results also can help predict the risk of diseases such as cancer, cardiovascular disease, hypertension and parasites, and Falciparum drug metabolism and drug benefit in this population.

Keywords:

personalized medicine , cytochrome P450 , CYP2C8 2 , polymorphism , cancer