Risk of Breast Cancer and Single – Nucleotide Polymorphism 2q35-rs13387042 in Persian women

Publish Year: 1395
نوع سند: مقاله کنفرانسی
زبان: English
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IPMCMED01_118

تاریخ نمایه سازی: 23 آذر 1397

Abstract:

Detection and characterization of the genetic diversity of Disease - associated loci are a major emphasis of current scientific inquiry in cancer. Rapid technological advances have enabled us to explore the increasingly complex genetic architectures and their relationship to cancer.Single nucleotide polymorphisms (SNPs) lead to genetic differences in breast cancer (BC) susceptibility among women from different ethnicities. Because compared to genetic variants located outside genes, genic variants are frequently judged to be more likely to alter gene function and affect disease risk.Genome-wide association studies (GWAS ) have identified some non-genic breast cancer susceptibility loci. Validation studies showed inconsistent results among different populations.The rs13387042 polymorphism at chromosome 2q35 has been identified as a new hotspot for breast cancer susceptibility by a recent GWA study.GWAS have identified 2q35-rs13387042 as a new breast cancer (BC) susceptibility locus in populations of European descent.Associations between the 2q35- rs13387042 polymorphism and breast cancer have been independently replicated by subsequent studies; however, a proportion of them have produced contrary results. Growing evidence suggests substantial heterogeneity by tumor subtype, defined by hormone receptor status, for association with the polymorphism.A recent genome-wide association study identified (SNP) 2q35 -rs13387042 as a marker of susceptibility to estrogen receptor (ER) – positive breast cancer.Roger L. et al. found strong evidence of association between rs13387042 and breast cancer in white women of European origin. Since then, the relationship between 2q35-rs13387042 and breast cancer has been reported in various ethnic groups.To investigate association with breast cancer among Iranian women, we genotype one nongenic polymorphism 2q35: rs13387042 using ARMS- PCR in BC patients and controls.

Authors

Ali Hajizadeh

Islamic Azad University, islamshahr

Mojgan Hoseini

Islamshahr Branch, Islamic Azad University, Islamshahr, Iran

Hamidreza Agha heydarali Naghash

Karaj Branch, Islamic Azad University,Karaj,Iran

Bahareh Abbasi

National Institute of Genetic Engineering and Biotechnology (NIGEB),Tehran,Iran