Systematic review: The role of Naringenin (Trihydroxyflavanone) on MCF-7 and BT- 483 Human Breast cancer cells

Background: Breast cancer is a major public health problem in women. Recently, natural treatments such as Naringenin (Nar) - a kind of flavonoids which it can be found in oranges, grapefruits and tomatoes- seem to be interesting. Nar can play a useful role in chemoprevention because it has pleiotropic effects on breast cancer cells. Methods: We performed a PRISMA-directed systematic review to investigate the effects of Naringenin on MCF-7 and BT- 483 human breast cancer cells. Primary outcomes were including: estrogenic properties, tumor size, cytotoxicity and apoptosis. The systematic search without restriction was conducted in the electronic databases including Cochrane Library, PubMed, Scopus and Google scholar before Oct 2016. Results: Initially, 739 articles were identified. After screening title and abstract, 37 studies were selected for text appraisal. Finally, 6 articles which met the inclusion criteria were evaluated. Cell proliferation and tumor growth can be prevented by Nar with different concentration. Also it can induce apoptosis. Conclusion: Probably mechanisms that provide anticancer properties of Nar are inducing alteration in caspase, aromatase enzymes and interdiction of oestrogen signal transduction pathways. So Nar may be used as food supplement or a potential therapeutic compound for breast cancer. It seems for determining the optimal dose, more investigations will be necessary in future.

Keywords:

Naringenin , breast cancer cells , MCF-7 , BT- 483 , systematic review