Fuchs Uveitis Syndrome in Iranian Patients: A Review of 89 eyes

Purpose: To describe clinical and imaging features of Fuchs Uveitis Syndrome (FUS) and investigate the rate of misdiagnosis in Iranian patients. Methods: Records of 82 FU patients (89 eyes) were reviewed retrospectively. Results: Remarkable findings included iris heterochromia in 14 (17.1%) patients and Fuchs keratic precipitates in 97.8%, vitritis in 89.7% and cataract in 69.7% eyes. FU discovered as an incidental finding in 7 patients (10.0%). Imaging revealed disc hyperfluorescence, mild vascular leakage and epiretinal membrane in 72.7%, 32.5% and 19.4 % of eyes, respectively. The rate of misdiagnosis was 19.5% (16 patients) with intermediate uveitis being as the most common erroneous diagnosis (10 patients). Patients with the wrong diagnosis were significantly younger (p=0.045) and more likely to have bilateral involvement (p=0.004) or no anterior chamber cells (p=0.039). Conclusion: Heterochromia is an infrequent clinical feature in Iranian FU patients; however, vitreous involvement is common. Intermediate uveitis is a usual misdiagnosis