Effect of Single Dose Antiglaucoma Medications on Choroidal Thickness

Purpose: it is believed that hemodynamic or thickness changes in choroid layer of the eye plays a fundamental role in pathogenesis of glaucoma. Studies have investigated the role of drugs and chemicals on choroid. However, we found no studies that investigate the effect of antiglaucoma drugs on choroid thickness. The aim of our study is to investigate the effect of some common antiglaucoma drugs on choroid thickness. Methods: 60 healthy young volunteers were classified into four groups: topical timolol eyedrop (15), topical dorzolamide eyedrop (15), topical brimonidine eyedrop (15) and topical latanoprost eyedrop (15). The right eye of each participant received drug eyedrop and the left eye received placebo eyedrop. Choroidal thickness in subfovea region was measured before eyedrop usage and two hours later for timolol, dorzolamide and brimonidine and 12 hours later for latanoprost eyedrop suing EDI-OCT (Heidelburg) .We planned to measure intraocular pressure but volunteers didn’t permit to do this. Data were gathered and analyzed using SPSS version 23. Results: from all 60 cases that were enrolled in the study, data of 53 cases were in access. The mean age of volunteers was 29.2±3.9. Thirty seven (69.8%) were males and 16 (30.2%) were females. There were no significant difference regarding mean differences or mean ranks between groups, before and after intervention, and between intervention and control eyes (P> 0.05). Conclusion: there was no significant difference between different intervention groups after drug usage regarding mean ranks of choroid layer thickness. This was similar for mean differences and mean ranks in before/after comparison of intervention and control eyes