Reno–Protective Effects of VitaminB12 on Aminoglycosides induced nephrotoxicity in rat

Background and Objective: Aminoglycosides are one of the common causes of drug-induced nephrotoxicity. The antioxidant, anti-inflammatory effect of Vitamin B12 was investigated on gentamicin nephrotoxicity in rats. Materials and Methods: Renal injury induced by i.p.injection of gentamicin (100 mg/kg) for 8 consecutive days. (6 mg/kg/day, i.p) treatment was done for 8 consecutive days as co-treatment and post-treatment protocol. Findings: Vitamin B12 significantly compensated deficits in the antioxidant defense mechanisms, suppressed lipid per oxidation and ameliorated renal tissue damage mediated by gentamicin. Conclusion: The results of the current study indicated VitaminB12 that effectively protected the kidney tissue against gentamicin induced acute nephrotoxicity in rats and increased anti-inflammatory defense.

Keywords:

Vitamin B12 , gentamicin induced nephrotoxicity , anti-inflammatory