Effect of ceftazidime and cloxacillin as an antibiotic permanent hemodialysis catheter blocker solution in the prevention of catheter-related bloodstream infections

Background and Objective: Patients with end-stage renal function (ESRD) require vascular access for hemodialysis and infection is the most common delayed complication of central venous catheters. The aim of this study was to evaluate the effect of using two antibiotics, ceftazidime and cloxacillin, as a permanent hemodialysis catheter blocker solution in the prevention of catheter-related blood infections. Materials and Methods: This clinical trial was performed on 64 patients undergoing hemodialysis in Tohid Hospital in Sanandaj, 2016-2017. Patients were divided into two groups of intervention and controls (placebo). The duration of follow up was 6 months in this study. All patients were evaluated during dialysis and in each session for further evaluations of unwanted drug reactions, skin complications such as rash, itching and other side effects. For data analysis, STATA software version 12, independent t-test and chi-square test were used. Findings: The results of this study showed that the mean duration of hemodialysis in the intervention group was 19.76±4.28 and the control group was 27.5±4.96 months. Most of the microorganisms have been grown in the blood culture of the subjects in both Staph Aureus groups. Conclusion: there was no statistically significant relationship between the use of the two antibiotics and the development of blood associated infections related to the hemodialysis catheter, although the number of hemodialysis catheter-related bloodstream infections in the control group was higher.

Keywords:

Hemodialysis , Catheter Infection , Antibiotic , CRBSI