The Role of LncRNAs in B-cell Malignancies

Background and Objective: Multiple myeloma is another example of B-cell malignancies and accounts for more than 1% of all cancers. Evidence suggests that non-coding RNAs undoubtedly have an undeniable function in hematological malignancies, such as multiple myeloma Evidence suggests that non-coding RNAs undoubtedly have an undeniable function in hematological malignancies, such as multiple myeloma. In these abnormalities, by use of replacement or inhibition of non-coding RNAs is emerging as a new novel way in treatment. In this review, we focus on long non-coding RNAs (lncRNAs) that are involved in multiple myeloma. We define the long non coding RNAs and indicate multiple myeloma-inclined list of lncRNAs, and describe some of the role of lncRNAs in cancer, as well as current and future research programs for lncRNAs for the treatment of cancers, especially multiple myeloma. Materials and Methods: PubMed, Scopusand Google Scholar were searched fromJanuary 2013 to December 2017. Based on inclusion and exclusion criteria ten relevant experimental studies with moderate bias were selected. The effect of the role of LncRNAs in B-cell malignancies was evaluated. Findings: Our analysis showed that the presently available evidence confirmed the therapeutic potential of LncRNAs in significantly Inhibition and improvement of B-cell malignancy symptoms. Conclusions: LncRNAs are an emerging field of investigation as they are suggested to regulate key biological processes, including cellular proliferation and differentiation, and their aberrant expression being strongly associated with cancer. An improved understanding of the role of ncRNAs in multiple myeloma would provide valuable information about key cancer-promoting pathways and might be highly useful for diagnostic and prognostic assessments. This knowledge might also lead to advancement in the management of multiple myeloma through the development of novel personalized ncRNA-based therapies.

Keywords:

LncRNAs , Cancer , B-cell Malignancy