Investigation of the prevalence of bone marrow involvement in patients ,Non-Hodgkin lymphoma , Shahid Bahonar Hospital , Kerman, Iran, 2015-2017

Background: In recent decades, an increase in the number of patients diagnosed with different types of lymphomas especially non-Hodgkin has been seen. Recognizing otherinvolved organs especially bone marrow has a great impact on determining , prognosis, survival and treatment modality in patients.Method: During years 2015-2017, clinical and pathological cases and immunohistochemistry results of patients with non-Hodgkin lymphoma that conductedbone marrow biopsy for staging, were investigated Findings: in three years, 99 patients with lymphoma that conducted bone marrow biopsy for staging, were identified. 59 of them were recognized non-Hodgkin by using histopathology and immunohistochemistry results of lymph nodes or other involved parts.Bone marrow involvement of these patients were determined based on bone marrow pathological results gained from bone marrow aspiration and biopsy. Review of aspirationand biopsy of these patients showed bone marrow involvement in 17 patients (28 percent) that males were four times more involved. Discussion: among 59 patients with non-Hodgkin lymphoma, bone marrow involvement was found in 17 patients, 11 of them were asked to do immunohistochemistry staining on bone marrow biopsy sample for confirmation of diagnosis. Considering that only unilateral biopsy from iliac spine is obtained in this center, no contradiction was seen between our results and other investigations.so trusting and siting the results of unilateral biopsy, seems to be correct. Results: according to other researches in the context of cancer prevalence in Kerman andits importance due to its increase and also treatment modality, noticing the bone marrow involvement have a great importance in patients follow up

Keywords:

non-Hodgkin lymphoma , Bone Marrow Involvement