Multicomponent reactions (MCRs) of electron-deficient acetylenes (dimethyl acetylenedicarboxylat (DMAD) and alkyl propiolates) with triphenylphosphine in the presence of the third reactant–A Mini review

Acetylenic esters such as dimethyl acetylenedicarboxylate (DMAD), diethyl acetylenedicarboxylate (DEAD) and alkyl propiolates are esters in which the ester groups are conjugated with a C-C triple bond. As such, these molecules are highly electrophilic, and widely employed as a dienophile in cycloaddition reactions. They have been used in muliticomponent reactions in the presence of nucleophilic compounds such as Isocyanides, Isoquinoline, Quinoline, Triphenylphosphine, trialkyl(aryl) phosphites and NH-acidic or OH-acidic compounds. This review mainly focuses on the research work reported in the scientific literature on the reaction this compounds with Triphenylphosphine

Keywords:

Dimethyl acetylenedicarboxylate , Triphenylphosphine , Diethyl acetylenedicarboxylate , Alkyl propiolates