Evaluation of Toxicity of Cobalt Ferrite Nanoparticles on Human Leukemia Cancer Cell Line K562

In this study, cobalt Ferrite nanoparticles with inverse spinel structures were obtained using co-precipitation of cobalt and iron nitrates. Ammonia 15% was used as an alkaline agent for pH adjustment. Besides, we used oleic acid to coat the cobalt ferrite nanoparticles.XRD analysis showed that the samples included spinel ferrite structure. According to the results of SEM the distribution of the particles was homogeneous and the particles were uniform, and pseudo-spherical in shape. The magnetic properties of the material were analyzed by the VSM that showed the relationship between super-paramagnetic properties of the material and particle size.In this research, for the first time, anti-cancer effects of cobalt ferrite nanoparticles on K562 cell line as an experimental model of acute myeloid leukemia (CML) were examined. Because this compound has the potential to induce differentiation and apoptosis, it can be used in conjunction with other pharmaceutical compounds as a promising candidate for the treatment of blood cancer patients.

Keywords:

Cobalt Ferrite , Nanoparticles , Chronic Myeloid Leukemia (CML) , Apoptosis , Cell K562