Development of a new molecularly imprinted polymer method for determination of Phenylephrine hydrochloride in drug sample

A molecularly imprinted polymer (MIP) for the determination of Phenylephrine hydrochloride (PHE) was present for the first time. The MIP was prepared by electropolymerization using 4-Aminobenzoic acid as the functionalmonomer, and Phenylephrine hydrochloride (PHE) as the template. The imprinting effect was verified by comparing electrochemical response of MIP and none imprinted polymer (NIP) tested by cyclic voltammetry between -0.6 and 1 V in redox peak currents of hexacyanoferrate. Some parameters affecting sensor response were optimized and then a calibration curve plotted. A dynamic linear range of 0.1µM to 1.0mM was obtained. The detection limit was 0.05µM (S/N=3). This imprinted electrochemical sensor was used successfully for PHE determination in real sample.

Keywords:

Molecularly imprinted polymer , Electropolymerization , Phenylephrine hydrochloride (PHE) , 4-Aminobenzoic acid , Coldax