EFFECT OF AGE-RESTRICTED DIET ON THE GLYCEMIC CONTROL, LIPID PROFILE, OXIDATIVE STRESS AND SYSTEMIC INFLAMMATION IN PATIENTS WITH METABOLIC SYNDROME: A RANDOMIZED CLINICAL TRIAL

Background and Aim: The aim was to elucidate the effect of AGEs restricted diet on lipid profile, inflammatory and oxidative stress markers and insulin resistance in patients with MetsMethods: 40 patients with Mets, were randomly assigned to take either a low AGE (L-AGE) (<15.000 kU/day) (n = 20) or a regular AGE (Reg-AGE) diet (n = 20) for eight weeks. Both groups were advised to follow an energy-balanced diet Results: After consumption of L-AGE diet, CML significantly reduced compared with the control group (-0.1 (SD 0.36) v. 0.29 (SD 0.44) μg/mL, P=0.004). Also, AGES restriction significantly reduced fasting blood glucose (FBG) (-1.55 (SD 2.2) v. -0.13 (SD 1.08) mg/dl, P=0.01) and homoeostatic model of assessment of insulin resistance in comparison to Reg-AGE (-3.1 (SD 6.1) v. 1.1 (SD 6.9), P=0.04). In addition, TNF_α (-3.1 (SD 4.5) v. -0.1 (SD 3.1) pg/ml, (P=0.02) as well as MDA (-1.1 (SD 2.0) v. 0.6 (SD 2.3) μmol/l, (P=0.02) were decreased significantly in the L-AGE group with respect to the group under Reg-AGE. Subjects with L-AGE diet showed a significant reduction in HDL-C compared with those subjects with Reg-AGE intake (-0.05 (SD 0.1) v. 0.03 (SD 0.1), P=0.006). Moreover, weight and WC decline (about triple) in L-AGE group (-3.5 (SD 1.1) v. -0.8 (SD 1.1), P=0.0001; -4.7 (SD 2.0) v. -1.5 (SD 1.5), P=0.0004, respectively)Conclusion: In conclusion, following to L-AGE can promote high FBS as Mets components and its main aetiological factors including insulin resistance and abdominal obesity. AGEs restriction could reduce systemic inflammation and oxidative stress markers

Keywords:

Metabolic syndrome , Obesity , Advanced glycation end products , Inflammation , Insulin resistance