EFFECTS OF GINGER SUPPLEMENTATION ALONG WITH NON-SURGICAL PERIODONTAL THERAPY ON GLYCEMIC CONTROL, LIPID PROFILE, INFLAMMATORY MARKERS AND ANTIOXIDANT AND PERIODONTAL STATUS IN TYPE 2 DIABETES MELLITUS PATIENTS WITH CHRONIC PERIODONTITIS

Background and Aim: The Objective of this study was to investigate the effects of ginger supplementation on glycemic control, lipid profile, some inflammatory markers and antioxidant and periodontal status in type 2 diabetic patients (T2DM) with chronic periodontitis (CP).Methods: In this double-blind clinical trial study, 50 T2DM patients with chronic periodontitis were randomly allocated to intervention and control groups. The intervention and control groups received either 2gr ginger or placebo (4 tablets) twice a day. Fasting blood glucose (FBG), glycosylated hemoglobin levels (HbA1c), triglyceride (TG), total cholesterol (CHOL), high-density (HDL), and low-density (LDL) lipoprotein cholesterol, very low-density lipoprotein (VLDL), Tumor necrosis factor alpha (TNF-α), High-sensitivity C-reactive Protein (hs.CRP), Total antioxidant capacity (TAC), Malondialdehyde (MDA), clinical attachment loss (CAL), bleeding on probing (BOP) were measured in all subjects both pre-intervention and post-intervention.Results: A significant reduction (P<0/05) was observed in the mean levels of HbA1c, FBG, TNF-α, hs.CRP, MDA and CAL in the intervention group, but there was no significant change in the mean levels of TG, CHOL, LDL-C, VLDL, TAC, BOP post-intervention. The mean serum level of HDL was significantly increased in the intervention group post intervention (P<0/05). There were significant differences in the mean changes of HbA1c, HDL, TNF-α, hs.CRP and CAL between intervention and control groups following intervention.Conclusion: It is recommended that ginger supplementation along with non-surgical periodontal Therapy may be effective in controlling the glycemic, lipid, inflammatory, antioxidant and periodontal status in T2DM with chronic periodontitis.

Keywords:

Type 2 diabetes mellitus , Periodontal disease , ginger , Lipid profile , Glycemic control , inflammatory markers , antioxidant status