ناشر تخصصی کنفرانس های ایران

لطفا کمی صبر نمایید

Publisher of Iranian Journals and Conference Proceedings

Please waite ..
Publisher of Iranian Journals and Conference Proceedings
Login |Register |Help |عضویت کتابخانه ها
Paper
Title

VITAMIN D ADMINISTRATION, COGNITIVE FUNCTION, BBB PERMEABILITY AND NEUROINFLAMMATORY FACTORS IN HIGH-FAT DIET-INDUCED OBESE RATS

Year: 1397
COI: INC15_230
Language: EnglishView: 168
نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

Authors

Ghazaleh Hajiluian - Student Research Committee, Faculty of public health Branch, Iran University of Medical Sciences,Tehran, Iran
ghazaleh nameni - Nutrition Research Center, Department of Community Nutrition, Tabriz University of Medical Sciences,Tabriz, Iran
jafari karegar - Student Research Committee, Faculty of public health Branch, Iran University of Medical Sciences, Tehran, Iran
mahdieh abbasalizad farhangi - Nutrition Research Center, Department of Community Nutrition, Tabriz University of Medical Sciences,Tabriz, Iran.

Abstract:

Background and Aim: The aims of current research were to investigate the effects of vitamin D administration on cognitive function, NF-κB, BDNF concentration in the hippocampus and BBB permeability in high-fat diet-induced obese rats.Methods: Forty male Wistar rats were divided into two groups: either control diet or high-fat diet for 16 weeks; then each group was randomized into two groups including: CD + Migliol, CD + vitamin D, HFD + Migliol and HFD + vitamin D. Vitamin D was administered at 500 IU kg-1 dosage for 5 weeks. Also, weight changes measured weekly. Five weeks after supplementation, Morris water maze test was performed to examine cognitive function. Moreover, BBB permeability was characterized by Evans blue dye in the hippocampus. NF-κB and BDNF concentrations in the hippocampus were determined using ELISA kits. Serum vitamin D concentration was also measured.Results: HFD led to significant impairments in learning and memory reduction measured by MWM test. Accordingly, increased NF- B (P=0.01) and decreased BDNF concentrations (P=0.04) was occurred in the hippocampus of HFD in comparison to CD group. Vitamin D supplementation reduced NF- B concentrations (P=0.001) and BBB permeability (P=0.03); while, BDNF concentrations increased (P=0.002) in the hippocampus of HFD + D group. Moreover, vitamin D led to a significant weight reduction (P=0.02) in HFD + D in comparison to HFD group. Vitamin D per se did not influence these changes in the hippocampi of rats fed CD + D versus CD.Conclusion: Vitamin D reversed HFD-induced cognitive impairments by reduction of the NF-κB and elevation of BDNF concentrations and modulation of the BBB permeability in rats hippocampus.

Keywords:

Paper COI Code

This Paper COI Code is INC15_230. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/816264/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Hajiluian, Ghazaleh and nameni, ghazaleh and jafari karegar, and abbasalizad farhangi, mahdieh,1397,VITAMIN D ADMINISTRATION, COGNITIVE FUNCTION, BBB PERMEABILITY AND NEUROINFLAMMATORY FACTORS IN HIGH-FAT DIET-INDUCED OBESE RATS,Third International Congress and Fifteenth Iranian Nutrition Congress,Tehran,https://civilica.com/doc/816264

Research Info Management

Certificate | Report | من نویسنده این مقاله هستم

اطلاعات استنادی این Paper را به نرم افزارهای مدیریت اطلاعات علمی و استنادی ارسال نمایید و در تحقیقات خود از آن استفاده نمایید.

Scientometrics

The specifications of the publisher center of this Paper are as follows:
Type of center: علوم پزشکی
Paper count: 3,702
In the scientometrics section of CIVILICA, you can see the scientific ranking of the Iranian academic and research centers based on the statistics of indexed articles.

New Papers

Share this page

More information about COI

COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

The COI is the national code of documents indexed in CIVILICA and is a unique and permanent code. it can always be cited and tracked and assumed as registration confirmation ID.

Support