RANDOMIZED CONTROLLED TRIAL INVESTIGATING THE EFFECTS OF AGARICUS BISPORUS ON ANTHROPOMETRIC INDICES, BLOOD PRESSURE AND LIVER ENZYMES IN SUBJECTS WITH TYPE 2 DIABETES MELLITUS

Background and Aim: The prevalence of NAFLD (non-alcoholic fatty liver disease) in diabetics is very high. Reducing obesity (especially abdominal obesity) is one of the approaches to improving complications of diabetes. Agaricus Bbisporus (AB), due to the high fiber, low calories and fat, is a good choice for diabetics.Methods: In this clinical trial, 16 g / day of dried AB or placebo was prescribed to patients with type 2 diabetes for 8 weeks (n = 22, in each group). 44 women and men aged 23-50 participated in this study.Results: After 8 weeks of intervention, there was no significant difference in weight, BMI (body mass index), waist circumference, hip circumference, WHR (waist to hip ratio) and WHtR (waist to height ratio). But in the intervention group, there was a significant reduction in within-group waist circumference (from 104/182 to 101/864 cm; p = 0.012) and WHtR (from 0/64 to 0/62; p = 0.014). The intervention group had lower body weight and BMI in comparison to baseline, but it was not significant (98.3 ± 1.01 and -1.32 ± 43.1, p < 0.05 respectively). The hepatic enzymes (ALT, AST, and ALP), and systolic and diastolic blood pressure at the end of the intervention did not differ significantly between the two groups (P 0.05).Conclusion: The results of our study failed to support the AB in protecting the liver. However, the improvement of anthropometric indices in the intervention group indicates the potential of AB in reducing the complications of type 2 diabetes. Long-term studies need to validate these findings.

Keywords:

Type 2 Diabetes , Agaricus Bisporus , Obesity , Hepatic enzymes