Hadiseh Hashemi yusefabad - Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences,Ahvaz, Iran
Seyed Ahmad Hosseini - Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences,Ahvaz, Iran
Mehrnoosh Zakerkish - Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences,Ahvaz, Iran
Bahman Cheraghian - Department of Epidemiology and Biostatistics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz,Iran

Background and Aim: To our knowledge, there has been no clinical trial for investigating the health benefits of Hot Air-dried White Button Mushroom (HAD-WBM) in type 2 diabetes. This study was carried out to determine the effects of HAD-WBM powder on glycemic indices, lipid profile, high sensitive C-reactive protein (hs-CRP), Interleukin-6 (IL-6), and total antioxidant capacity (TAC) in a double-blind, placebo-controlled clinical trial in type 2 diabetic patients.Methods: This study was conducted on 44 men and women aged 23-50 years with type 2 diabetes mellitus. Patients were randomly assigned to intervention and control groups. The intervention and control groups received 16 g/day HAD-WBM or cornstarch powder for 8 weeks.Results: After 8 weeks of intervention, a significant decrease was observed in serum concentration of fructosamine (-0.228± 0.36 vs. 0.03± 0.38 mmol/l; p = 0.022) and LDL-C (-13.05± 20.67 vs. 0.81± 21.79 mg/dl; p = 0.04) in the intervention group compared with control group, while the reduction in total cholesterol concentration was a trend (-14.40± 28.93 vs. 2.23± 25.73 mg/dl; p = 0.05). Fasting blood sugar (FBS), and homeostasis model assessment of insulin resistance (HOMA-IR) levels had no significant differences between two groups but was significantly lower in the intervention group compared to baseline(p = 0.006, p = 0.016, respectively). There was no significant difference in TAC, hs-CRP, and IL-6 between the two groups post-intervention.Conclusion: The results of this study suggest that HAD-WBM can help to improve glycemic indices and lipid profile in type 2 diabetic patients.

white button mushroom, hot air-dried, type 2 diabetes, insulin