THE INTERACTION OF CHOLESTERYL ESTER TRANSFER PROTEIN GENE VARIATIONS WITH DIET IN RELATION TO CHANGES OF SERUM LIPID PROFILES

Background and Aim: Gene-diet interactions may have a critical role in the inter-individual variations of lipid responses to diet. This study aimed to investigate whether polymorphisms (rs5882 and rs3764261) in the cholesteryl ester transfer protein (CETP) gene modify the relationship of diet with changes in serum lipid profiles.Methods: A total of 4700 individuals, aged ≥18 years were selected from participants of the Tehran Lipid and Glucose Study. After 3.6 years of follow-up, changes in serum lipid profiles were evaluated. Usual dietary intake was assessed using a validated food frequency questionnaire. Portions of DNA samples were genotyped with HumanOmniExpress-24-v1-0 bead chips (containing 649,932 SNP loci).Results: There was no significant interaction between CETP polymorphisms and dietary patterns in relation to lipid profiles. Mean changes in total cholesterol (TC) appeared to decrease in higher quartiles of fish intake in A allele carriers )Q1:8.02, Q4:5.58, Ptrend=0.01), compared to the CC genotype (Q1:3.65, Q4:8.93, Ptrend=0.11) (Pi=0.02). There are ascending trends of changes in triglyceride (TG) concentrations across quartiles of total fat, mono-unsaturated and saturated fat consumption in G allele carriers of rs5882, compared to the AA genotype. There was a descending trend for mean changes in TG concentrations across quartiles of carbohydrate intake in G allele carriers of rs5882 compared to the AA genotype (Pi=0.01).Conclusion: Our data suggest that minor allele carriers of rs5882 had a better TG concentration than AA homozygote subjects when they consumed a low fat and high carbohydrate diet. Fish intake modifies the association of rs3764261with TC concentrations.

Keywords:

Diet , CETP polymorphisms , Lipid profiles , Interaction