BENEFICIAL ANTI-OXIDATIVE AND METABOLIC EFFECTS OF LACTOBACILLUS PLANTARUM AND INULIN ON HYPOTHALAMUS IN DIABETIC RATS
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
INC15_258
تاریخ نمایه سازی: 30 دی 1397
Abstract:
Background and Aim: This study intended to evaluatethe effects of Lactobacillus plantarum (L.plantarum) and inulin on hypothalamic levels of insulin, leptin, and oxidative markers in diabetic rats.Methods: Diabetes was induced by high-fat diet and streptozotocin. The supplements were given to the rats for 8 weeks. Results: Results showed that serum glucose was reduced in the diabetes+L.plantarum (DL), diabetes+inulin (DI), and diabetes+L.plantarum+inulin (DLI) groups. The synbiotic showed increased serum insulin and leptin compared to diabetes sham (DSh) rats, and improved lipid profile compared to DSh and diabetes control (DC) groups. Hypothalamic levels of insulin, leptin, and superoxide dismutase were increased in the DLI group in contrast to DSh group. Malondialdehyde was reduced in the DL, DI, and DLI groups compared to DC group. Conclusion: Therefore, L.plantarum and/or inulin can exert antidiabetic and antioxidant properties via improving insulin resistance, hyperlipidemia as well as hypothalamic levels of insulin, leptin, and oxidative markers in Type 2 diabetes mellitus.
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Authors
Elahe Hosseinifard
Student Research Committee, TabrizUniversity of Medical Sciences, Tabriz, Iran
Khadijeh Bavafa Valenlia
Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences,Tabriz, Iran
Mohammad Morshedi
Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences,Tabriz, Iran
Maryam Saghafi-Asl
Department of Biochemistry and Diet Therapy, School of Nutrition and Food Sciences, TabrizUniversity of Medical Sciences, Tabriz, Iran