SURVEY OF RELATIONSHIP BETWEEN DIETARY INTAKE OF VITAMIN E AND LEVELS OF HS-CRP AND MDA IN PATIENTS WITH HYPERLIPIDEMIA

Background and Aim: Hyperlipidemia is associated with chronic inflammatory diseases like atherosclerosis. Epidemiological studies suggest that increased dietary intake of antioxidants reduces the risk of coronary artery disease by suppressing inflammation. The aim of the present study was to examine whether dietary intake of vitamin E affects sensitivity C-reactive protein (hs-CRP) and malone aldehyde (MDA) levels in hyperlipidemic patients.Methods: In this analytical cross-sectional study, 40 hyperlipidemic patients (ages 26 - 67 y) were randomly selected from health care centers. 24-hour recall questionnaire was also completed in 3 continuous days. Serum levels of hs-CRP and MDA were determined. The data were entered in SPSS software version 16.0 and were analyzed by correlation tests. Significant was set at P value < 0.05.Results: A reverse significant correlation was observed between dietary intake of vitamin E with levels of hs-CRP. In fact, subjects with higher vitamin E intake levels had statistically significant lower levels of hs-CRP, that significance level was (P value < 0.03, r=0.62). No significant relation was found between dietary intake of vitamin E with MDA levels in patients with hyperlipidemia.Conclusion: Results showed that greater dietary intake of of vitamin E via normal food could improve hs-CRP levels in patients with hyperlipidemia. Further clinical studies are suggested to confirm the results.

Keywords:

vitamin E , hs-CRP , MDA , hyperlipidemia