THE EFFECT OF SYNBIOTICS SUPPLEMENTATION ON ANTHROPOMETRIC INDICATORS AND LIPID PROFILES IN WOMEN WITH POLYCYSTIC OVARY SYNDROME: A RANDOMIZED DOUBLE BLIND PLACEBO CONTROLLED TRIAL

Background and Aim: Different therapies have been suggested for polycystic ovary syndrome (PCOS), but changes in lifestyle and diet have been considered. Diet and dietary factors can be very effective in modifying the disease. The positive effects of probiotic and synbiotics supplementation on improving lipid profiles and anthropometric indices have been examined in various diseases. This study was conducted to evaluate the effects of synbiotics supplementation on lipid and anthropometric profilesin infertile women with PCOS. Methods: PCOS patients aged 19–37 years old were randomized to receive either synbiotics supplement (n = 44) or placebo (n = 44) for 12 weeks. Consumption of synbiotics compared to the placebo,Results: resulted in a significant decrease in Low-density lipoprotein cholesterol (LDL) value (Change Mean Difference (CMD): 4.66, 95%CI: 0.20 to 9.13) and a significant increase in high-density lipoprotein cholesterol (HDL) (CMD: 1.80, 95%CI: 0.34 to 3.26).Conclusion: Although we failed to find a significant effect of synbiotics consumption on total cholesterol (TC) and triglyceride (TG) levels. We did not find differences in anthropometric indices between groups. Overall, 12 weeks of synbiotics supplementation among PCOS women resulted in beneficial effects on LDL and HDL; however, it did not affect TG, TC and anthropometric indices.

Keywords:

Polycystic Ovary Syndrome , Synbiotics , Cholesterol , LDL , Cholesterol , HDL , Triglyceride