ASSOCIATION BETWEEN OBESITY AND INFLAMMATION AMONG DIABETIC POLYNEUROPATHY PATIENTS

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

INC15_399

تاریخ نمایه سازی: 30 دی 1397

Abstract:

Background and Aim: Inflammation is defined as body tissues response to harmful stimuli. Obesity-related inflammation leads to increased risk chronic diseases including diabetic polyneuropathy (DPN). The present study was performed to determine association between body mass index (BMI) and inflammatory markers including erythrocyte sedimentation rate (ESR) and C−reactive protein (CRP).Methods: In this cross-sectional study, two-hundred DPN patients with mean age of 58.76 were selected. All patients completed the questionnaire including demographic data, chronic disease histoy, anthropometric measures and clinical laboratory tests. Multiple linear regression was used to detect the association between levels of CRP and ESR and BMI.Results: Based on the results, ESR and CRP levels significantly increased with body mass index (β-ESR=5.07, p<0.001 and β-CRP=0.74, p<0.001). Also, this association remained after adjustment for other different variables.Conclusion: These findings indicate that in general higher BMIs is related to inflammatory markers including CRP and ESR. Therapies for DPN and reducing inflammation should target the weight loss among obese patients

Authors

Tayebeh Mottaghi

PhD student of nutrition, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan,Iran.

Fariborz Khorvash

Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran

Gholamreza Askari

Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

Mohammadreza Maracy

Departments of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences,Isfahan, Iran