EFFECT OF VITAMIN D SUPPLEMENTATION ON SUPEROXIDE DISMUTASE ANTIOXIDANT ENZYME AND INFLAMMATORY FACTORS IN CHILDREN WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
INC15_425
تاریخ نمایه سازی: 30 دی 1397
Abstract:
Background and Aim: ADHD is the most common children s psychiatric disorder with oxidative stress and inflammation condition as playing role in the development of this. The aim of this study was to determine the effect of vitamin D supplementation on antioxidant activity of superoxide dismutase (SOD) and inflammatory mediators in children with ADHD.Methods: This double-blind clinical trial was performed in 70 children (6-13 years) with ADHD diagnosed by the pediatric psychologist and receiving maintenance therapy. Patients were randomly assigned to receive either a single capsule of 1000 IU vitamin D (n = 35) or placebo (n = 35) daily for 12 weeks. The serum levels of C-reactive protein (CRP), interleukin-6 (IL-6), Homocysteine and the activity of superoxide dismutase (SOD) were determined before and after the intervention.Results: In the intervention group, the mean serum vitamin D and SOD significantly increased significantly after intervention (P<0.001), but the mean serum CRP and IL-6 levels were significantly lower than the intervention before intervention (P<0.001). Independent t-test showed that the average of changes in vitamin D (P<0.001), SOD (P=0.001), IL-6 (P<0.001) and serum CRP (P<0.001) after intervention were significant, but the mean of homocysteine changes in the two groups was not significantly less than the placebo group before the intervention in the intervention group (P=0.46).Conclusion: The present clinical trial study showed that vitamin D supplementation can reduce CRP and IL-6 and increase SOD in children with ADHD. The physiological variation in vitamin D may have an important role in ADHD.
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Authors
Iman Namjoo
Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
Amirmansour Alavi Naeini
Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
Mostafa Najafi
Department of Psychiatry, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Mohammad Reza Aghaye Ghazvini
Isfahan Center of Health Research, National Institute of Health Research, Isfahan, Iran