Fateme Rahimi - Nutritional Sciences Department, Faculty of Nutrition and Food Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran
Yahya Pasdar - Nutritional Sciences Department, Faculty of Nutrition and Food Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran
Golbon Sohrab - Department of Clinical Nutrition and Dietetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Soheil Abbasi - Nutritional Sciences Department, Faculty of Nutrition and Food Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background and Aim: Obesity and metabolic disorders have ever-increasing rate in adult population and impose a great amount of financial expenses on health systems worldwide. The present study was conducted to determine effects of synbiotic supplementation with educating low-calorie diet on metabolic syndrome (MetS) components in individuals with MetS.Methods: 108 subjects aged 25-65 year with MetS participated in this double-blind randomized clinical controlled trial. Subjects in Synbiotic group (n=52) were received 1000mg/day synbiotic supplement (Familact®, Zist Takhmir) and those in Placebo group were consumed the same amount of standard placebo capsules for 12 weeks. All the participant were taught how to follow a healthy, low-calorie diet.Results: Outcomes of this trial exhibited a significant decrease in serum FBS (P=0.007) and Total Cholesterol (TC) (P=0.04) between two groups after the intervention. TC concentration (P=0.007) also were declined in Synbiotic group compared to baseline. Serum triglycerides (TG) and systolic blood pressure (SBP) decrement inclined to be significant in both Synbiotic (P=0.001, P=0.03) and Placebo (P<0.001, P<0.001) groups, respectively. A moderate improvement of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and diastolic blood pressure (DBP) in both groups were observed. Waist circumference (WC) significantly attenuated in both groups (P<0.001), as well.Conclusion: Outcomes of this study suggests that synbiotic supplementation with low-calorie diet can be effective in improving FBS, TG and TC concentration, and alleviating HDL-C serum level, WC and BP. Therefore, the combination of this two interventions can result in a more efficient management of MetS indices.

Metabolic Syndrome; Glycaemia; Lipid Profile; Low-Calorie Diet