ASSOCIATIONS OF VITAMIN D STATUS AND RISK OF DEVELOPING CARDIOVASCULAR RISK FACTORS, INSULIN RESISTANCE AND HYPERTRIGLYCERIDEMIC WAIST PHENOTYPE IN APPARENTLY HEALTHY ADULTS

Background and Aim: Previous studies have explored the relation of Vitamin D deficiency. Vitamin D deficiency is associated with cardiovascular disease. A relationship between vitamin D levels and. The purpose of this study is to evaluate the relationship between vitamin D status, cardiovascular disease, Insulin resistance and the hypertriglyceridemic waist phenotype (HTGWP).Methods: A total of 265 healthy adults were examined, HTGWP was described as serum triacylglycerol concentrations > 150 mg/dL and concurrent WC > 88 cm (women) and > 102 cm (men). We measured BP, hs-CRP, Lipid profiles and insulin resistance as a cardiovascular risk factors.Results: : Current study’s results demonstrated that HTGWP was significantly associated with age, WC, weight, hip, fat percent, TG, lipid profile, ALT and BMI. Mediated effects model showed that in addition to vitamin D deficiency, insulin has a mediator role in the development of CVD and has a direct effect (p for trend=0.04) and (p for trend=0.08). However, our results revealed that vitamin D deficiency, compared with normal status, can increase the risk of phenotype 1 (high TG/high WC); OR: 3.86 and 95%CI from 0.86 to 0.99, p for trend=0.05. In the multivariate models after adjusted for confounders, likewise the risk of vitamin d deficiency on developing phenotype 1 was stronger; OR: 4.07 and 95%CI from 0.48 to 0.95, P for trend= 0.04. Conclusion: Significant associations were found between vitamin D status and HTGWP. In addition, there was a relationship between vitamin D and CVD.

Keywords:

Vitamin D status , cardiovascular disease , Hypertriglyceridemic waist phenotype